In recent years, nano-drug technology is a popular new technology in drug preparation technology. Nano drugs such as nanoparticles, ball or nano capsule nanoparticles as a carrier system, and the efficacy of particles in a certain way together after the medicine, can also be made directly to the technical processing of nanoparticles.
Compared with conventional drugs, nano-drugs have many advantages that are incomparable to conventional drugs:
A slow release drug, changing the half-life of the drug in the body, prolonging the action time of the drug;
A specific target organ can be reached after being made into a guided drug;
To reduce the dosage, reduce or eliminate the toxic side effect under the premise of ensuring the efficacy;
The membrane transport mechanism is changed to increase the permeability of the drug to the biofilm, which is beneficial to the drug transdermal absorption and the play of the drug efficacy.
So for those needs with the help of a carrier to deliver drugs to specific targets, give play to the role of treatment in terms of nanodrugs, the design of the carrier to improve the efficiency of drug targeting is crucial.
Recently the news bulletin said the university of new south wales, Australia, the researchers developed a new method, can change the shape of nano drug carrier, this will help the transport of anti-cancer drugs released into the tumor, improve the effect of anti-cancer drugs.
Polymer molecules in solution can be automatically formed vesicle hollow spherical structure of the polymer, it has the advantages of strong stability, functional diversity are widely used as drug carrier, but, by contrast, such as bacteria and virus in the nature are tubes, rods, and the non spherical biological structures can be more easily enter the body. Because the polymer vesicles are difficult to form a nonspherical structure, this limits the ability of the polymer to deliver drugs to its destination in the human body to a certain extent.
Australian researchers used cryoelectron microscopy to observe the structural changes of polymer molecules in solution. They found that by changing the amount of water in the solvent, the shape and size of the polymer vesicles could be adjusted by changing the amount of water in the solvent.
Study lead author and university of new south wales institute of chemistry of pine parr sol, said: “this breakthrough means we can produce polymer vesicle shape may change with the environment, such as the oval or tubular, and drug package in it.” Preliminary evidence suggests that the more natural, non-spherical nano-drug carriers are more likely to enter tumor cells.
The research was published online in the latest issue of the journal nature communications.